Challenges and future directions of potential natural products leads against 2019-nCoV outbreak

Meirambek Ospanov; Francisco León; Janar Jenis; IKhlas A Khan; Mohamed A Ibrahim

doi:10.1016/j.cpb.2020.100180

Challenges and future directions of potential natural products leads against 2019-nCoV outbreak

Curr Plant Biol. 2020 Dec:24:100180. doi: 10.1016/j.cpb.2020.100180. Epub 2020 Oct 8.

Authors

Meirambek Ospanov^{1

2}, Francisco León³, Janar Jenis², IKhlas A Khan¹, Mohamed A Ibrahim^{1

4}

Affiliations

¹ National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
² The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi ave. 71, 050040, Almaty, Kazakhstan.
³ Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA.
⁴ Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, 12622, Cairo, Egypt.

Abstract

Except for Remdesivir® no other drug or vaccine has yet been approved to treat the coronavirus disease (COVID-19) caused by the virus known as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Remdesivir® an small molecule and nucleic acid analogue, it is used to treat adults and children with laboratory confirmed COVID-19, only administrated in hospital settings. Small molecules and particularly natural products count for almost fifty percent of the commercially available drugs, several of them are marketed antiviral agents and those can be a potential agent to treat COVID-19 infections. This short review rationalized different key natural products with known activity against coronaviruses as potential leads against COVID-19.

Keywords: 2019-nCoV; Coronaviruses; Natural products; SARS-CoV-2.

Publication types

Review