Taurine up-regulated gene 1 and disease development

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020;45(9):1127-1135. doi: 10.11817/j.issn.1672-7347.2020.190181.
[Article in English, Chinese]

Abstract
in English, Chinese

Long non-coding RNA (lncRNA) have been attracted attention due to its role in many diseases. Taurine up-regulated gene 1(TUG1)is a non-coding RNA of 7.1 kb in length, which locates on chromosome 22q12. More and more studies have found that TUG1 not only participates in the occurrence and development of tumors, but also plays an important role in the progression of diseases in cardiovascular system, endocrine system, nervous system and so on. It is expected to become the therapeutic targets and indicators for evaluating prognosis of a variety of diseases such as diabetes, myocardial ischemia, osteoarthritis, atherosclerosis and so on.

长链非编码RNA因在许多疾病中发挥了重要的作用而成为人们日益关注的焦点。牛磺酸上调基因1(taurine up-regulated gene 1，TUG1)是一种长度为7.1 kb，位于染色体22q12上的非编码RNA，它不仅参与肿瘤的发生、发展，而且在心血管、内分泌、神经系统等多种疾病的进展中起重要作用，并有望成为多种疾病(如糖尿病、心肌缺血、骨关节炎、动脉粥样硬化等)的治疗靶点及评估预后的指标。.

Keywords: long non-coding RNA; prognosis of disease; taurine up-regulated gene 1.

MeSH terms

  • Atherosclerosis*
  • Humans
  • MicroRNAs*
  • Prognosis
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / physiology
  • Taurine

Substances

  • MicroRNAs
  • RNA, Long Noncoding
  • TUG1 long noncoding RNA, human
  • Taurine