Rspos and malignant tumors of digestive system

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020;45(9):1115-1119. doi: 10.11817/j.issn.1672-7347.2020.190333.
[Article in English, Chinese]

Abstract
in English, Chinese

Roof plate specific spondins (Rspos) are important activators of the Wnt signaling pathway discovered recently. Rspos include four secreted proteins: Rspo1, Rspo2, Rspo3, and Rspo4.They are mainly involved in the regulation of cell proliferation and differentiation via regulating the canonical Wnt/β-catenin signaling pathway.The physiological functions of Rspos include regulating sex selection, limb development, organ formation and development. Rspos are involved in the pathogenesis of some malignant tumors, and the roles of Rspos vary in different types of tumors.

特异性顶部盘状底板反应蛋白(roof plate specific spondins，Rspos)是新近发现的Wnt信号通路的重要激活因子，包括Rspo1~4四种分泌蛋白质。Rspos主要通过调节经典Wnt/β-catenin信号通路来调控细胞的增殖与分化，其主要生理功能包括调节性别选择、肢体发育和器官形成与发育等。此外，Rspos还参与了部分恶性肿瘤的发病过程，且在不同类型肿瘤中的作用并不一致。.

Keywords: Wnt/β-catenin signaling pathway; malignant tumors; roof plate specific spondins.

MeSH terms

  • Cell Proliferation
  • Digestive System
  • Humans
  • Neoplasms*
  • Thrombospondins*
  • Wnt Signaling Pathway

Substances

  • Thrombospondins