Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy

Muhammad Babar Khawar; Chao Liu; Fengyi Gao; Hui Gao; Wenwen Liu; Tingting Han; Lina Wang; Guoping Li; Hui Jiang; Wei Li

doi:10.1007/s13238-020-00771-1

Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy

Protein Cell. 2021 Jan;12(1):67-75. doi: 10.1007/s13238-020-00771-1. Epub 2020 Oct 13.

Authors

Muhammad Babar Khawar^#^{1

2}, Chao Liu^#^{1

2}, Fengyi Gao^#³, Hui Gao¹, Wenwen Liu^{1

2}, Tingting Han⁴, Lina Wang^{1

2}, Guoping Li⁵, Hui Jiang^{6

7

8

9}, Wei Li^{10

11}

Affiliations

¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ School of Biotechnology and Food, Shangqiu Normal University, Shangqiu, 476000, China.
⁴ The MOH key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China.
⁵ The MOH key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China. guoping_li@yahoo.com.
⁶ Department of Urology, Peking University Third Hospital, Beijing, 100191, China. jianghui55@163.com.
⁷ Department of Andrology, Peking University Third Hospital, Beijing, 100191, China. jianghui55@163.com.
⁸ Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing, 100191, China. jianghui55@163.com.
⁹ Department of Human Sperm Bank, Peking University Third Hospital, Beijing, 100191, China. jianghui55@163.com.
¹⁰ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. leways@ioz.ac.cn.
¹¹ University of Chinese Academy of Sciences, Beijing, 100049, China. leways@ioz.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autophagy / genetics*
Cholesterol / metabolism*
Gene Expression Regulation*
Integrases / genetics
Integrases / metabolism
Leydig Cells / cytology
Leydig Cells / metabolism*
Male
Mice
Mice, Knockout
Multienzyme Complexes / genetics
Multienzyme Complexes / metabolism
Phosphoproteins / genetics
Phosphoproteins / metabolism
Primary Cell Culture
Progesterone Reductase / genetics
Progesterone Reductase / metabolism
RNA Splicing Factors / genetics
RNA Splicing Factors / metabolism
Scavenger Receptors, Class B / genetics
Scavenger Receptors, Class B / metabolism
Sequestosome-1 Protein / genetics
Sequestosome-1 Protein / metabolism
Signal Transduction
Sirtuin 1 / deficiency
Sirtuin 1 / genetics*
Sodium-Hydrogen Exchangers / genetics
Sodium-Hydrogen Exchangers / metabolism
Steroid 17-alpha-Hydroxylase / genetics
Steroid 17-alpha-Hydroxylase / metabolism
Steroid Isomerases / genetics
Steroid Isomerases / metabolism
Testosterone / biosynthesis*
Testosterone / genetics

Substances

Multienzyme Complexes
Phosphoproteins
RNA Splicing Factors
Scarb1 protein, mouse
Scavenger Receptors, Class B
Sequestosome-1 Protein
Sf1 protein, mouse
Sodium-Hydrogen Exchangers
Sqstm1 protein, mouse
sodium-hydrogen exchanger regulatory factor
steroidogenic acute regulatory protein
Testosterone
Cholesterol
Hsd3b1 protein, mouse
Progesterone Reductase
Steroid 17-alpha-Hydroxylase
Cre recombinase
Integrases
Sirt1 protein, mouse
Sirtuin 1
Steroid Isomerases