Manganese Exposure and Neurologic Outcomes in Adult Populations

Kaitlin V Martin; David Edmondson; Kim M Cecil; Cassandra Bezi; Miriam Leahshea Vance; Dani McBride; Erin N Haynes

doi:10.1016/j.ncl.2020.07.008

Manganese Exposure and Neurologic Outcomes in Adult Populations

Neurol Clin. 2020 Nov;38(4):913-936. doi: 10.1016/j.ncl.2020.07.008. Epub 2020 Sep 12.

Authors

Kaitlin V Martin¹, David Edmondson², Kim M Cecil³, Cassandra Bezi⁴, Miriam Leahshea Vance⁵, Dani McBride⁶, Erin N Haynes⁷

Affiliations

¹ Department of Epidemiology, College of Public Health, University of Kentucky, 111 Washington Avenue Room 212C, Lexington, KY 40536, USA. Electronic address: Kaitlin.vollet.martin@uky.edu.
² Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Imaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5033, Cincinnati, OH 45229, USA.
³ Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Imaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5033, Cincinnati, OH 45229, USA; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
⁴ Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7017, Cincinnati, OH 45229, USA.
⁵ Department of Epidemiology, College of Public Health, University of Kentucky, 111 Washington Avenue, Lexington, KY 40536, USA.
⁶ Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
⁷ Department of Epidemiology, College of Public Health, University of Kentucky, 111 Washington Avenue Room 212G, Lexington, KY 40536, USA.

Abstract

A review of published articles examining the effects of manganese exposure to workers and community residents shows adverse neurologic outcomes. Innovative biomarkers, including those from neuroimaging, were incorporated into many of these studies to assess both manganese exposure and neurologic outcomes. A variety of health effects were evaluated, including cognitive and motor impairments. Studies of community participants residing near manganese point sources show variability in outcomes, reflecting the complexities of exposure measurement, individual absorption, and assessment of neurologic effects. The aging population provides insight into the impacts of chronic exposure in younger populations.

Keywords: Brain; Cognition; Manganese; Motor.

Publication types

Review

MeSH terms

Aged
Humans
Manganese / adverse effects*
Middle Aged
Neurotoxicity Syndromes / etiology*

Substances

Manganese

Abstract

Publication types

MeSH terms

Substances

Grants and funding