Occupational exposure to the diacetyl flavoring may cause bronchiolitis obliterans (BO) in workers. The first case of flavoring-related bronchiolitis obliterans was reported in 2002. Since then, similar cases have been identified among workers in various production industries in some countries and regions. At present, there are no cases reported in China. In order to improve the awareness of the disease and promote the prevention work, this article reviews the research progress of case recognition, risk factors, clinical manifestation and possible pathogenesis.
职业接触双乙酰香味剂可能导致作业人员闭塞性细支气管炎（BO）。自2002年双乙酰香味剂相关性BO病例报道以来，部分国家和地区的不同生产工业工人均有类似病例报道。目前国内尚未见相关病例报道。本文综述了双乙酰香味剂相关性BO的认识历程、职业接触机会、疾病临床表现以及可能发病机制的研究进展，以期提高对疾病的认识，推动预防工作的开展。.
Keywords: 2, 3-Butanedione; Bronchiolitis, obliterans; Diacetyl flavoring; Occupational diseases; Risk factors.