Abstract
The dynamic Schiff base bond is exploited to construct monodisperse dopamine-based nanoparticles with autofluorescence and pH-sensitivity. This allows facile monitoring and pH-responsive drug release in the acidic tumor microenvironment. Anticancer drugs doxorubicin and a photosensitizer chlorin e6 are further loaded into the nanoparticles and synergistic anticancer efficacy is achieved.
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Chlorophyllides
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Dopamine / chemistry*
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Doxorubicin / chemistry
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Doxorubicin / pharmacology
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Drug Carriers / chemistry*
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Drug Liberation
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Drug Synergism
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Humans
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Hydrogen-Ion Concentration
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Nanoparticles / chemistry*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology
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Porphyrins / chemistry
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Porphyrins / pharmacology
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Schiff Bases / chemistry*
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Tumor Microenvironment / drug effects
Substances
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Antineoplastic Agents
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Chlorophyllides
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Drug Carriers
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Photosensitizing Agents
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Porphyrins
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Schiff Bases
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phytochlorin
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Doxorubicin
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Dopamine