In-hospital mortality and morbidity among extremely preterm infants in relation to maternal body mass index

Sanjay Chawla; Abbot R Laptook; Emily A Smith; Sylvia Tan; Girija Natarajan; Myra H Wyckoff; Namasivayam Ambalavanan; Edward F Bell; Krisa P Van Meurs; David K Stevenson; Erika F Werner; Rachel G Greenberg; Abhik Das; Seetha Shankaran; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network

doi:10.1038/s41372-020-00847-0

In-hospital mortality and morbidity among extremely preterm infants in relation to maternal body mass index

J Perinatol. 2021 May;41(5):1014-1024. doi: 10.1038/s41372-020-00847-0. Epub 2020 Oct 6.

Authors

Sanjay Chawla¹, Abbot R Laptook², Emily A Smith³, Sylvia Tan³, Girija Natarajan⁴, Myra H Wyckoff⁵, Namasivayam Ambalavanan⁶, Edward F Bell⁷, Krisa P Van Meurs⁸, David K Stevenson⁹, Erika F Werner¹⁰, Rachel G Greenberg¹¹, Abhik Das¹², Seetha Shankaran⁴; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network

Affiliations

¹ Department of Pediatrics, Wayne State University, Detroit, MI, USA. schawla@dmc.org.
² Department of Pediatrics, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
³ RTI International, Washington, DC, USA.
⁴ Department of Pediatrics, Wayne State University, Detroit, MI, USA.
⁵ Department of Pediatrics, UT Southwestern Medical Center at Dallas, Dallas, TX, USA.
⁶ Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
⁷ Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
⁸ Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
⁹ Department of Pediatrics/Neonatology, Stanford University, Palo Alto, CA, USA.
¹⁰ Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
¹¹ Department of Pediatrics, Duke University, Durham, NC, USA.
¹² Social, Statistical, and Environmental Sciences Unit, RTI International, Rockville, MD, USA.

Abstract

Objective: The objective of this paper is to compare in-hospital survival and survival without major morbidities in extremely preterm infants in relation to maternal body mass index (BMI).

Methods: This retrospective cohort study included extremely preterm infants (gestational age 22^0/7-28^6/7 weeks). This study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. Primary outcome was survival without any major morbidity.

Results: Maternal BMI data were available for 2415 infants. Survival without any major morbidity was not different between groups: 30.8% in the underweight/normal, 28.1% in the overweight, and 28.5% in the obese (P = 0.65). However, survival was lower in the obese group (76.5%) compared with overweight group (83.2%) (P = 0.02). Each unit increase in maternal BMI was associated with decreased odds of infant survival (P < 0.01).

Conclusions: Survival without any major morbidity was not associated with maternal obesity. An increase in maternal prepregnancy BMI was associated with decreased odds of infant survival.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Body Mass Index
Child
Female
Hospital Mortality
Humans
Infant
Infant, Extremely Premature*
Infant, Newborn
Morbidity
Overweight*
Pregnancy
Retrospective Studies

Abstract

Publication types

MeSH terms

Grants and funding