Angiotensin-converting Enzyme 2-containing Small Extracellular Vesicles and Exomeres Bind the Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein

Gastroenterology. 2021 Feb;160(3):958-961.e3. doi: 10.1053/j.gastro.2020.09.042. Epub 2020 Oct 3.

Authors

Qin Zhang¹, Dennis K Jeppesen¹, James N Higginbotham¹, Jeffrey L Franklin¹, James E Crowe Jr², Robert J Coffey³

Affiliations

¹ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
² Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
³ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: robert.coffey@vumc.org.

No abstract available

MeSH terms

ADAM17 Protein / metabolism
Angiotensin-Converting Enzyme 2 / metabolism*
COVID-19 / enzymology*
COVID-19 / virology
Caco-2 Cells
Dipeptidyl Peptidase 4 / metabolism
Extracellular Vesicles / enzymology*
Extracellular Vesicles / virology
Host-Pathogen Interactions
Humans
Membrane Proteins / metabolism
Protein Binding
SARS-CoV-2 / metabolism*
Serine Endopeptidases / metabolism
Spike Glycoprotein, Coronavirus / metabolism*
Virus Internalization*

Substances

Membrane Proteins
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
DPP4 protein, human
Dipeptidyl Peptidase 4
ACE2 protein, human
Angiotensin-Converting Enzyme 2
Serine Endopeptidases
TMPRSS2 protein, human
TMPRSS4 protein, human
ADAM17 Protein
ADAM17 protein, human

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