Local Bacteriotherapy - a promising preventive tool in recurrent respiratory infections

Expert Rev Clin Immunol. 2020 Nov;16(11):1047-1052. doi: 10.1080/1744666X.2021.1833720. Epub 2020 Oct 15.

Abstract

Introduction: Children with recurrent respiratory infections (RRI) represent a social issue for the economic burden and the negative family impact. Local Bacteriotherapy is an attractive therapeutic strategy that could be potentially effective in preventing infections. The current article remarks on the existing evidence of preventing RRI by Local Bacteriotherapy.

Areas covered: The literature search methodology was based on the articles cited by PubMed from 1980 to 2020. Respiratory infections include rhino-pharyngitis, otitis media, rhinosinusitis, pharyngo-tracheitis, bronchitis, and pneumonia. Several studies were performed to investigate the effects of Local Bacteriotherapy in children with RRI. Both intranasal and oral Local Bacteriotherapy were evaluated. The findings showed that Local Bacteriotherapy significantly reduced the number of RI episodes, their severity, the use of antibiotics, and school absences.

Expert opinion: Local Bacteriotherapy is a promising approach to RRI prevention and could be a profitable strategy to contrast infections in the future.

Keywords: Streptococcus oralis89a; Streptococcus salivarius 24SMB; Local Bacteriotherapy; Recurrent respiratory infections; children; nasal spray; oral spray.

Publication types

  • Review

MeSH terms

  • Administration, Intranasal
  • Administration, Oral
  • Biological Therapy / methods*
  • Child
  • Humans
  • Recurrence
  • Respiratory Tract Infections / therapy*
  • Streptococcus oralis / physiology*
  • Streptococcus salivarius / physiology*
  • Treatment Outcome