M-health applications are playing an important role in current healthcare delivery, individual's health and well-being. Usability of mHealth applications (apps) is a critical factor for the success of the apps, yet this is often overlooked in the current health care solutions in primary care, secondary (acute) care, community care and especially in remote patient monitoring applications. This work aimed to co-design the vital signs monitoring application with end-users and clinicians. The co-design user-experience includes goals and objectives, participant inclusion and exclusion criteria, task list, testing documentation, laboratory-based usability testing and data analysis for identifying gaps and opportunities. The study found two main issues from the usability analysis, presentation of the information such as use of icons, text and graphs and clinical workflow related matters such as the number of mandatory steps required to finish a task.