A new dimeric monoterpene indole alkaloid polonidine A (1), along with five known compounds, cyclopenol (2), verrucosidin (3), fructigenine A (4), 3-O-methylviridicatin (5) and aurantiomides C (6), were isolated from Penicillium polonicum TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 exhibited moderate cytotoxic activities and moderate antibacterial activity against Bacillus subtilis with MIC of 4.0 μg/mL.
Keywords: Penicillium polonicum TY12; Polonidine A; cytotoxic activity; dimmer; monoterpene indole alkaloid.