Molybdenum disulfide-gold nanoparticle nanocomposite in field-effect transistor back-gate for enhanced C-reactive protein detection

Mikrochim Acta. 2020 Oct 5;187(11):588. doi: 10.1007/s00604-020-04562-7.

Abstract

Nanofabricated gold nanoparticles (Au-NPs) on MoS2 nanosheets (Au-NPs/MoS2) in back-gated field-effect transistor (BG-FET) are presented, which acts as an efficient semiconductor device for detecting a low concentration of C-reactive protein (C-RP). The decorated nanomaterials lead to an enhanced electron conduction layer on a 100-μm-sized transducing channel. The sensing surface was characterized by Raman spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), atomic force microscopy (AFM), scanning electron microscopy (SEM), and high-power microscopy (HPM). The BG-FET device exhibits an excellent limit of detection of 8.38 fg/mL and a sensitivity of 176 nA/g·mL-1. The current study with Au-NPs/MoS2 BG-FET displays a new potential biosensing technology; especially for integration into complementary metal oxide (CMOS) technology for hand-held future device application.

Keywords: C-reactive protein; Field-effect transistor; Gold nanoparticles; Molybdenum disulfide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Immobilized / immunology
  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods
  • C-Reactive Protein / analysis*
  • C-Reactive Protein / immunology
  • Disulfides / chemistry
  • Electric Conductivity
  • Electrochemical Techniques / instrumentation
  • Electrochemical Techniques / methods
  • Gold / chemistry
  • Humans
  • Limit of Detection
  • Metal Nanoparticles / chemistry*
  • Molybdenum / chemistry
  • Nanocomposites / chemistry*
  • Reproducibility of Results
  • Transistors, Electronic*

Substances

  • Antibodies, Immobilized
  • Disulfides
  • Gold
  • Molybdenum
  • C-Reactive Protein
  • molybdenum disulfide