The clinical utilities of multi-pinhole single photon emission computed tomography

Ilker Ozsahin; Ling Chen; Arda Könik; Michael A King; Freek J Beekman; Greta S P Mok

doi:10.21037/qims-19-1036

The clinical utilities of multi-pinhole single photon emission computed tomography

Quant Imaging Med Surg. 2020 Oct;10(10):2006-2029. doi: 10.21037/qims-19-1036.

Authors

Ilker Ozsahin^{1

2

3}, Ling Chen¹, Arda Könik⁴, Michael A King⁵, Freek J Beekman^{6

7

8}, Greta S P Mok^{1

9}

Affiliations

¹ Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, China.
² Department of Biomedical Engineering, Faculty of Engineering, Near East University, Nicosia/TRNC, Mersin-10, Turkey.
³ DESAM Institute, Near East University, Nicosia/TRNC, Mersin-10, Turkey.
⁴ Department of Imaging, Dana Farber Cancer Institute, Boston, MA, USA.
⁵ Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA.
⁶ Section of Biomedical Imaging, Department of Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
⁷ MILabs B.V, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
⁸ Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.
⁹ Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Macau, China.

Abstract

Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very successful application in small animal imaging, there has been a resurgence of the use of MPH collimators for clinical cardiac and brain studies, as well as other small field-of-view applications. This article reviews the basic principles of MPH collimators and introduces currently available and proposed clinical MPH SPECT systems.

Keywords: Single photon emission computed tomography (SPECT); brain; cardiac; collimator; multi-pinhole.

Publication types

Review