Engineered biomaterials for heart disease

Curr Opin Biotechnol. 2020 Dec:66:246-254. doi: 10.1016/j.copbio.2020.08.008. Epub 2020 Oct 1.

Abstract

Ischemic heart disease is the most common type of heart disease, responsible for roughly 10 million deaths worldwide annually. While standard clinical interventions have resulted in improved patient outcomes, access to small diameter vessels required for cardiovascular interventions, and long-term patient mortality rates associated with eventual heart failure, remain critical challenges. In this current opinion piece we discuss novel methodologies for the advancement of vascular grafts, cardiac patches, and injectable drug delivery depot technologies as they relate to treatment of ischemic heart disease, including bilayered conduits, acellular bioactive extracellular matrix (ECM) scaffolds, and protease-responsive hydrogel delivery platforms. We address the motivation for innovation and current limitations in the field of engineered biomaterials for myocardial ischemia therapeutics and interventions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biocompatible Materials*
  • Extracellular Matrix
  • Heart Diseases* / surgery
  • Humans
  • Hydrogels
  • Tissue Engineering
  • Tissue Scaffolds

Substances

  • Biocompatible Materials
  • Hydrogels