The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study

Youta Torii; Shuji Iritani; Hirotaka Sekiguchi; Chikako Habuchi; Hiroshige Fujishiro; Itaru Kushima; Ito Kawakami; Masanari Itokawa; Makoto Arai; Shotaro Hayashida; Katsuhisa Masaki; Jun-Ichi Kira; Kunihiro Kawashima; Norio Ozaki

doi:10.1016/j.schres.2020.09.012

The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study

Schizophr Res. 2020 Sep:223:356-358. doi: 10.1016/j.schres.2020.09.012. Epub 2020 Sep 29.

Authors

Affiliations

¹ Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan; Department of Psychiatry, Moriyama General Psychiatric Hospital, 11-50 Machikita, Moriyama-ku, Nagoya, Aichi 463-8570, Japan. Electronic address: youtat@med.nagoya-u.ac.jp.
² Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan. Electronic address: iritani@med.nagoya-u.ac.jp.
³ Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan.
⁴ Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan. Electronic address: kushima@med.nagoya-u.ac.jp.
⁵ Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address: kawakami-it@igakuken.or.jp.
⁶ Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address: itokawa-ms@igakuken.or.jp.
⁷ Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address: arai-mk@igakuken.or.jp.
⁸ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: shoutaro@neuro.med.kyushu-u.ac.jp.
⁹ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
¹⁰ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp.
¹¹ Department of Psychiatry, Moriyama General Psychiatric Hospital, 11-50 Machikita, Moriyama-ku, Nagoya, Aichi 463-8570, Japan. Electronic address: k-kawash@fujita-hu.ac.jp.
¹² Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan. Electronic address: ozaki-n@med.nagoya-u.ac.jp.

PMID: 33008688
DOI: 10.1016/j.schres.2020.09.012

No abstract available

Keywords: Advanced glycation end-products; Carbonyl stress; GLO1 frameshift mutation; Glyoxalase 1; Postmortem study; Schizophrenia.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Autopsy
Frameshift Mutation
Glycation End Products, Advanced
Humans
Lactoylglutathione Lyase* / genetics
Schizophrenia* / complications
Schizophrenia* / genetics

Substances

Glycation End Products, Advanced
Lactoylglutathione Lyase