Synthesis of graphene quantum dots and their applications in drug delivery

Changhong Zhao; Xuebin Song; Ya Liu; Yifeng Fu; Lilei Ye; Nan Wang; Fan Wang; Lu Li; Mohsen Mohammadniaei; Ming Zhang; Qiqing Zhang; Johan Liu

doi:10.1186/s12951-020-00698-z

Synthesis of graphene quantum dots and their applications in drug delivery

J Nanobiotechnology. 2020 Oct 2;18(1):142. doi: 10.1186/s12951-020-00698-z.

Authors

Changhong Zhao^{1

2}, Xuebin Song³, Ya Liu⁴, Yifeng Fu⁴, Lilei Ye⁵, Nan Wang⁵, Fan Wang³, Lu Li³, Mohsen Mohammadniaei⁶, Ming Zhang⁶, Qiqing Zhang⁷, Johan Liu^{8

9}

Affiliations

¹ School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, 453003, P. R. China. 15921061530@163.com.
² Electronics Materials and Systems Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96, Gothenburg, Sweden. 15921061530@163.com.
³ School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, 453003, P. R. China.
⁴ Electronics Materials and Systems Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96, Gothenburg, Sweden.
⁵ SHT Smart High-Tech AB, 411 33, Gothenburg, Sweden.
⁶ Department of Health Technology, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
⁷ School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, 453003, P. R. China. Zhangqiq@126.com.
⁸ Electronics Materials and Systems Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96, Gothenburg, Sweden. johan.liu@chalmers.se.
⁹ School of Automation and Mechanical Engineering, SMIT Center, Shanghai University, No 20, Chengzhong Road, Box 808, ShanghaiShanghai, 201800, China. johan.liu@chalmers.se.

Abstract

This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

Keywords: Bottom-up; Delivery-release mode; Drug delivery; Graphene quantum dots; Top-down.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Drug Delivery Systems / methods*
Drug Liberation
Graphite / chemical synthesis*
Magnetics
Mice
Oxidation-Reduction
Particle Size
Photothermal Therapy
Quantum Dots / chemistry*

Substances

Antineoplastic Agents
Graphite

Grants and funding

18A430026/Education Department of Henan Province (CN)