Terpenes isolated from Polyalthia simiarum and their cytotoxic activities

Xiao-Yan Duan; Kun-Yuan Guo; Dong-Jin Lv; Ren-Qiang Mei; Mei-De Zhang

doi:10.1016/j.fitote.2020.104734

Terpenes isolated from Polyalthia simiarum and their cytotoxic activities

Fitoterapia. 2020 Nov:147:104734. doi: 10.1016/j.fitote.2020.104734. Epub 2020 Sep 29.

Authors

Xiao-Yan Duan¹, Kun-Yuan Guo², Dong-Jin Lv³, Ren-Qiang Mei⁴, Mei-De Zhang⁵

Affiliations

¹ Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China.
² Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China.
³ Department of Medical Oncology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650118, PR China.
⁴ Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: meirenqiang@mail.kib.ac.cn.
⁵ Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China. Electronic address: emailtoecho@163.com.

PMID: 33007399
DOI: 10.1016/j.fitote.2020.104734

Abstract

Two new C₃₁ triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined by analysis of 1D and 2D NMR data. Three new compounds were tested for their cytotoxicity against five human tumour cell lines. Compound 3 showed cytotoxic activities against SMMC-7721 with the IC₅₀ value of 22.43 μM.

Keywords: Clerodane diterpenoids; Cytotoxic activities; Polyalthia simiarum; Triterpenes.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
China
Diterpenes, Clerodane / isolation & purification
Diterpenes, Clerodane / pharmacology*
Humans
Molecular Structure
Plant Leaves / chemistry
Polyalthia / chemistry*
Terpenes / isolation & purification
Terpenes / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Diterpenes, Clerodane
Terpenes