Bullous vesicant-type reaction to docetaxel along the venous tract: A case report

Jane Su; Laurence Bernard; Sophia Colantonio; Alexander Norgaard; Hal W Hirte; Lua Eiriksson

doi:10.1016/j.gore.2020.100640

Bullous vesicant-type reaction to docetaxel along the venous tract: A case report

Gynecol Oncol Rep. 2020 Sep 11:34:100640. doi: 10.1016/j.gore.2020.100640. eCollection 2020 Nov.

Authors

Jane Su¹, Laurence Bernard^{1

2}, Sophia Colantonio³, Alexander Norgaard⁴, Hal W Hirte⁵, Lua Eiriksson²

Affiliations

¹ DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
² Division of Gynecologic Oncology, Juravinski Hospital & Cancer Centre, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
³ Department of Dermatology, University of Ottawa, Ontario, Canada.
⁴ Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
⁵ Division of Medical Oncology, Juravinski Hospital & Cancer Centre, Department of Oncology, McMaster University, Hamilton, Ontario, Canada.

Abstract

Docetaxel is an anti-neoplastic agent commonly used to treat major solid tumors. Common toxicities of docetaxel include neutropenia, alopecia, nausea and vomiting. While docetaxel is typically considered an irritant, we present the case report of a 54-year-old female with high-grade undifferentiated uterine sarcoma who experienced a standard infusion reaction during a docetaxel infusion, followed by an atypical, delayed vesicant-type reaction, without a clear extravasation history.

Keywords: Chemotherapy; Docetaxel; Reaction; Vesicant.

Publication types

Case Reports