Recent Update on the Anti-infective Potential of β-carboline Analogs

Faheem; Banoth Karan Kumar; Kondapalli Venkata Gowri Chandra Sekhar; Selvaraj Kunjiappan; Joazaizulfazli Jamalis; Rafael Balaña-Fouce; Murugesan Sankaranarayanan

doi:10.2174/1389557520666201001130114

Recent Update on the Anti-infective Potential of β-carboline Analogs

Mini Rev Med Chem. 2021;21(4):398-425. doi: 10.2174/1389557520666201001130114.

Authors

Faheem¹, Banoth Karan Kumar¹, Kondapalli Venkata Gowri Chandra Sekhar², Selvaraj Kunjiappan³, Joazaizulfazli Jamalis⁴, Rafael Balaña-Fouce⁵, Murugesan Sankaranarayanan¹

Affiliations

¹ Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Vidya Vihar, Pilani-333031, Rajasthan, India.
² Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, R.R. Dist. Hyderabad, 500078, Telangana, India.
³ Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil 626126, India.
⁴ Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia.
⁵ Department of Biomedical Sciences; University of Leon, 24071 Leon, Spain.

PMID: 33001013
DOI: 10.2174/1389557520666201001130114

Abstract

β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and antithrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.

Keywords: PYRIDO indole; antibacterial; antifungal; antiprotozoal; antiviral; β-Carboline.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Anti-Infective Agents / chemical synthesis
Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology*
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Antiprotozoal Agents / chemical synthesis
Antiprotozoal Agents / chemistry
Antiprotozoal Agents / pharmacology
Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Bacteria / drug effects
Bacterial Infections / drug therapy
Carbolines / chemical synthesis
Carbolines / chemistry*
Carbolines / pharmacology*
Chemistry Techniques, Synthetic
Drug Discovery
Fungi / drug effects
Humans
Mycoses / drug therapy
Protozoan Infections / drug therapy
Virus Diseases / drug therapy
Viruses / drug effects

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Antifungal Agents
Antiprotozoal Agents
Antiviral Agents
Carbolines