The oxygen evolution reaction (OER) with sluggish kinetics is a bottleneck for the large-scale application of water electrolysis. Herein, solid-solution hexagonal Ni0.5Co0.5Se nanoflakes are designed and successfully synthesized via a facile hydrothermal method with a much lower overpotential of 216 mV at 10 mA cm-2 and a Tafel slope of 37.08 mV dec-1.