Polypharmacy and mobility outcomes

Muhammad Usman Ali; Diana Sherifali; Donna Fitzpatrick-Lewis; Meghan Kenny; April Liu; Larkin Lamarche; Derelie Mangin; Parminder Raina

doi:10.1016/j.mad.2020.111356

Polypharmacy and mobility outcomes

Mech Ageing Dev. 2020 Dec:192:111356. doi: 10.1016/j.mad.2020.111356. Epub 2020 Sep 28.

Authors

Muhammad Usman Ali¹, Diana Sherifali², Donna Fitzpatrick-Lewis³, Meghan Kenny⁴, April Liu⁵, Larkin Lamarche⁶, Derelie Mangin⁷, Parminder Raina⁸

Affiliations

¹ McMaster Evidence Review and Synthesis Team, McMaster University, 1280 Main St. W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Room HSC-2C, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada. Electronic address: aliu@mcmaster.ca.
² McMaster Evidence Review and Synthesis Team, McMaster University, 1280 Main St. W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada; School of Nursing, Faculty of Health Sciences, McMaster University, Health Sciences Centre Room HSC-3N25F, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. Electronic address: dsherif@mcmaster.ca.
³ McMaster Evidence Review and Synthesis Team, McMaster University, 1280 Main St. W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada; School of Nursing, Faculty of Health Sciences, McMaster University, Health Sciences Centre Room HSC-3N25F, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. Electronic address: fitzd@mcmaster.ca.
⁴ McMaster Evidence Review and Synthesis Team, McMaster University, 1280 Main St. W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Room HSC-2C, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada. Electronic address: mkenny@mcmaster.ca.
⁵ McMaster University, 1280 Main St. W., Hamilton, Ontario, L8S 4L8, Canada. Electronic address: april.liu@medportal.ca.
⁶ McMaster University, Dept. of Family Medicine DBHSC, 5th Floor 100 Main St West, Hamilton,Ontario L8P 1H6, Canada. Electronic address: lamarche@mcmaster.ca.
⁷ McMaster University, Dept. of Family Medicine DBHSC, 5th Floor 100 Main St West, Hamilton,Ontario L8P 1H6, Canada. Electronic address: mangind@mcmaster.ca.
⁸ McMaster Evidence Review and Synthesis Team, McMaster University, 1280 Main St. W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Room HSC-2C, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada. Electronic address: praina@mcmaster.ca.

PMID: 32991919
DOI: 10.1016/j.mad.2020.111356

Abstract

Polypharmacy is known to be associated with negative consequences of mobility related conditions such as falls, functional decline and disability. This systematic review highlights the effectiveness of deprescribing interventions on mobility related conditions in older adults in the community dwelling reported taking five or more medications daily.

Keywords: Chronic disease; Mobility; Multi-morbidity; Older adults; Polypharmacy.

Publication types

Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Aged
Deprescriptions*
Humans
Inappropriate Prescribing* / adverse effects
Inappropriate Prescribing* / prevention & control
Independent Living
Mobility Limitation*
Multiple Chronic Conditions / drug therapy*
Outcome Assessment, Health Care
Polypharmacy*

Grants and funding

PJT 148971/CIHR/Canada