SeDeM Expert System, an Innovative Tool for Developing Directly Compressible Tablets: A Review

Curr Drug Res Rev. 2021;13(1):16-24. doi: 10.2174/2589977512666200928113716.

Abstract

Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameters derived diagram that can be used as a research tool for reducing the product development time. The best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability.

Objective: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs.

Conclusion: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail.

Keywords: SeDeM; SeDeM-ODT; application; direct compression; excipients; tablets.

Publication types

  • Review

MeSH terms

  • Chemistry, Pharmaceutical / methods*
  • Delayed-Action Preparations
  • Drug Compounding / methods*
  • Drug Development / methods
  • Excipients / chemistry*
  • Expert Systems
  • Humans
  • Pressure
  • Tablets
  • Time Factors

Substances

  • Delayed-Action Preparations
  • Excipients
  • Tablets