Current Results of Surgical Treatment of Craniopharyngiomas: The Impact of Endoscopic Endonasal Approaches

Joao Paulo Almeida; Aristotelis Kalyvas; Nilesh Mohan; Selfy Oswari; Hirokazu Takami; Carlos Velasquez; Mohammed Asha; Gelareh Zadeh; Fred Gentili

doi:10.1016/j.wneu.2020.05.174

Current Results of Surgical Treatment of Craniopharyngiomas: The Impact of Endoscopic Endonasal Approaches

World Neurosurg. 2020 Oct:142:582-592. doi: 10.1016/j.wneu.2020.05.174.

Authors

Joao Paulo Almeida¹, Aristotelis Kalyvas², Nilesh Mohan², Selfy Oswari², Hirokazu Takami², Carlos Velasquez², Mohammed Asha², Gelareh Zadeh², Fred Gentili³

Affiliations

¹ Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
² Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
³ Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: fred.gentili@uhn.ca.

PMID: 32987614
DOI: 10.1016/j.wneu.2020.05.174

Abstract

Surgery is the main treatment option for the management of craniopharyngiomas. Transcranial microsurgical approaches, such as pterional and subfrontal approaches, have constituted the classic operative strategy for resection of these tumors. However, the development of endoscopic endonasal approaches has revolutionized the treatment of craniopharyngiomas in the last 15 years, and endoscopic resection is favored for most craniopharyngiomas. In this article, we discuss our experience with the management of craniopharyngiomas and review the current results of the surgical treatment of those tumors, including discussion of goals of surgery, complications, recurrences, and the role of adjuvant treatment.

Keywords: Craniopharyngioma; Endoscopic; Microsurgery; Results; Surgery.

Publication types

Review

MeSH terms

Cerebrospinal Fluid Leak / epidemiology*
Craniopharyngioma / diagnostic imaging
Craniopharyngioma / physiopathology
Craniopharyngioma / surgery*
Humans
Hypopituitarism / epidemiology
Hypopituitarism / physiopathology*
Margins of Excision
Microsurgery
Nasal Cavity
Natural Orifice Endoscopic Surgery / methods*
Neoplasm Recurrence, Local
Neuroendoscopy / methods*
Pituitary Neoplasms / diagnostic imaging
Pituitary Neoplasms / physiopathology
Pituitary Neoplasms / surgery*
Postoperative Cognitive Complications / epidemiology
Postoperative Complications / epidemiology*
Treatment Outcome
Vision Disorders / physiopathology*