Vaccines Against Tuberculosis: Problems and Prospects (Review)

N I Nadolinskaia; D S Karpov; A V Goncharenko

doi:10.1134/S0003683820050129

Vaccines Against Tuberculosis: Problems and Prospects (Review)

Appl Biochem Microbiol. 2020;56(5):497-504. doi: 10.1134/S0003683820050129. Epub 2020 Sep 22.

Authors

N I Nadolinskaia¹, D S Karpov², A V Goncharenko¹

Affiliations

¹ Bach Institute of Biochemistry, Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.
² Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Abstract

Despite the efforts of the global medical and scientific community, tuberculosis remains the leading cause of death from infectious diseases. The expectation of success associated with the development of new anti-TB drugs was not justified, and the attention of researchers was largely drawn to the creation of new mycobacterial strains for vaccination against tuberculosis. The proposed review contains current information on the existing vaccine strains and the development of new, genetically engineered strains for the prevention of tuberculosis and the prevention and treatment of other diseases. The review includes relevant information on the correlation between BCG vaccination and the frequency and severity of COVID-19 infection.

Keywords: BCG; recombinant vaccine; tuberculosis; vaccine.