Response to: The mitochondria-targeted antioxidant MitoQ attenuates exercise-induced mitochondrial DNA damage (Williamson et al., available online 6 August 2020, 101,673)

Johannes Burtscher; Martin Burtscher; Grégoire P Millet

doi:10.1016/j.redox.2020.101732

Response to: The mitochondria-targeted antioxidant MitoQ attenuates exercise-induced mitochondrial DNA damage (Williamson et al., available online 6 August 2020, 101,673)

Redox Biol. 2021 Jan:38:101732. doi: 10.1016/j.redox.2020.101732. Epub 2020 Sep 17.

Authors

Johannes Burtscher¹, Martin Burtscher², Grégoire P Millet³

Affiliations

¹ Institute of Sport Sciences, University of Lausanne, CH-1015, Lausanne, Switzerland. Electronic address: johannes.burtscher@unil.ch.
² University of Innsbruck, A-6020, Innsbruck, Austria.
³ Institute of Sport Sciences, University of Lausanne, CH-1015, Lausanne, Switzerland.

Abstract

Williamson and colleagues present important data on the effects of MitoQ - an antioxidant compound targeted to mitochondria - on mtDNA damage following exercise. Future studies are needed to elucidate, whether or not the observed prevention of MitoQ on DNA damage is beneficial with regard to functional outcomes in healthy, exercising humans in dependence of the exercise stimulus and individual characteristics of the person.

Keywords: DNA-Damage; Exercise; MitoQ; Mitochondria; Reactive oxygen species; Supplementation.

Publication types

Comment

MeSH terms

Antioxidants* / pharmacology
DNA Damage
DNA, Mitochondrial* / genetics
Humans
Mitochondria
Organophosphorus Compounds
Reactive Oxygen Species
Ubiquinone / pharmacology

Substances

Antioxidants
DNA, Mitochondrial
Organophosphorus Compounds
Reactive Oxygen Species
Ubiquinone