Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial

J Lauren Ruoss; Catalina Bazacliu; Jordan T Russell; Diomel de la Cruz; Nan Li; Matthew J Gurka; Stephanie L Filipp; Richard A Polin; Eric W Triplett; Josef Neu

doi:10.1016/j.jpeds.2020.09.056

Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial

J Pediatr. 2021 Feb:229:294-298.e3. doi: 10.1016/j.jpeds.2020.09.056. Epub 2020 Sep 23.

Authors

Affiliations

¹ Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL. Electronic address: lruoss@ufl.edu.
² Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL.
³ Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL.
⁴ Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL.
⁵ Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY.

Abstract

We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.

Keywords: dysbiosis; infants; microbiome; sepsis.

Publication types

Randomized Controlled Trial
Research Support, N.I.H., Extramural

MeSH terms

Age Factors
Anti-Bacterial Agents / therapeutic use*
Female
Humans
Infant, Newborn
Infant, Premature
Male
Pilot Projects
Streptococcal Infections / drug therapy*
Streptococcus agalactiae*

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding