The purpose of the current study was to investigate the prevalence of depressive symptomatology before termination of pregnancy due to fetal anomaly and to analyze associated risk factors. A cross-sectional study was performed in the obstetric departments of six hospitals in Hunan, China. Depressive symptomatology was measured before termination of pregnancy using the Edinburgh Postpartum Depression Scale. t test, analysis of variance, and binary logistic regression tests were used in the data analysis of depressive symptomatology and factors. A total of 65.6% (n = 177) of participants were identified with depressive symptomatology before termination. Risk factors were receipt of spousal support, self-efficacy, religious belief, history of adverse pregnancy outcomes, and sleep disturbance. Protective factors were engagement with health care providers, social support, and higher monthly family income. Nurses should be aware of these factors early on to prevent the occurrence of depressive symptomatology, thereby improving maternal mental health. [Journal of Psychosocial Nursing and Mental Health Services, 58(12), 43-50.].
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