GPER as a Receptor for Endocrine-Disrupting Chemicals (EDCs)

Front Endocrinol (Lausanne). 2020 Aug 19:11:545. doi: 10.3389/fendo.2020.00545. eCollection 2020.

Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with endogenous hormonal systems at various levels, resulting in adverse health effects. EDCs belong to diverse chemical families and can accumulate in the environment, diet and body fluids, with different levels of persistence. Their action can be mediated by several receptors, including members of the nuclear receptor family, such as estrogen and androgen receptors. The G protein-coupled estrogen receptor (GPER), a seven-transmembrane domain receptor, has also attracted attention as a potential target of EDCs. This review summarizes our current knowledge concerning GPER as a mediator of EDCs' effects.

Keywords: GPER; endocrine-disrupting chemicals (EDCs); estrogen; hormone; pathophysiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Endocrine Disruptors / metabolism*
  • Environmental Pollutants / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Receptors, Estrogen / genetics
  • Receptors, Estrogen / metabolism*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Endocrine Disruptors
  • Environmental Pollutants
  • GPER1 protein, human
  • Receptors, Estrogen
  • Receptors, G-Protein-Coupled