Blood-Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

Yingxi Wu; Haijian Wu; Xinying Guo; Brock Pluimer; Zhen Zhao

doi:10.3389/fphys.2020.01030

Blood-Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

Front Physiol. 2020 Aug 21:11:1030. doi: 10.3389/fphys.2020.01030. eCollection 2020.

Authors

Yingxi Wu¹, Haijian Wu^{1

2}, Xinying Guo¹, Brock Pluimer^{1

3}, Zhen Zhao^{1

3}

Affiliations

¹ Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute and Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
² Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
³ Neuroscience Graduate Program, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Abstract

Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a robust environmental risk factor for neurodegenerative diseases including Alzheimer's disease (AD). Besides direct neuronal injury and neuroinflammation, blood-brain barrier (BBB) dysfunction is also a hallmark event of the pathological cascades after mTBI. However, the vascular link between BBB impairment caused by mTBI and subsequent neurodegeneration remains undefined. In this review, we focus on the preclinical evidence from murine models of BBB dysfunction in mTBI and provide potential mechanistic links between BBB disruption and the development of neurodegenerative diseases.

Keywords: blood-brain barrier; mild traumatic brain injury; murine model; neurodegenerative diseases; vascular link.

Publication types

Review

Abstract

Publication types

Grants and funding