How Do Tumor-Treating Fields Work?

Kristen W. Carlson; Jack A. Tuszynski; Socrates Dokos; Nirmal Paudel; Thomas Dreeben; Ze’ev Bomzon

doi:10.1007/978-3-030-45623-8_2

How Do Tumor-Treating Fields Work?

Review

In: Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting [Internet]. Cham (CH): Springer; 2021.

2020 Aug 6.

Authors

Kristen W. Carlson¹, Jack A. Tuszynski², Socrates Dokos³, Nirmal Paudel⁴, Thomas Dreeben⁵, Ze’ev Bomzon⁶

Book Editors

Sergey N. Makarov¹, Gregory M. Noetscher¹, Aapo Nummenmaa²

Affiliations

¹ Department of Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
² Department of Physics, University of Alberta, Edmonton, AB, Canada
³ Department of Biomedical Engineering, University of New South Wales, Sydney, Australia
⁴ Independent Consultant, Greenville, NC, USA
⁵ OSRAM Opto Semiconductors, Exeter, NH, USA
⁶ Novocure Ltd. Haifa, Israel

Book Affiliations

¹ Electrical and Computer Engineering Department, Worcester Polytechnic Institute, Worcester, MA, USA
² Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital, Charlestown, MA, USA

Excerpt

Since approved by the FDA for the treatment of glioblastoma brain cancer in 2015, tumor-treating fields (TTFields) have rapidly become the fourth modality to treat cancer, along with surgery, chemotherapy, and radiation [1]. TTFields are now in clinical trials for a variety of cancer types. While efficacy has been proven in the clinic, the higher efficacy is demonstrated in vitro and in animal models, which indicates much greater clinical efficacy is possible. To attain the great promise of TTFields, uncovering the mechanisms of action (MoA) is necessary.

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