Fibronectin structure and composition regulate contextual cell signaling. Recent advances have been made in understanding fibronectin and its role in tissue organization and repair. This review outlines fibronectin splice variants and their functions, evaluates potential therapeutic strategies targeting or utilizing fibronectin, and concludes by discussing potential future directions to modulate fibronectin function in development and wound healing.
Keywords: Development; Fibronectin; Isoforms; Regeneration; Splice variants; Wound healing.
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.