The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes

Abstract

Introduction: This study was aimed to explore the relationship between neural network changes in newly diagnosed children with Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) and cognitive impairment.

Methods: Children's cognition was evaluated using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Magnetoencephalographic (MEG) data of 18 healthy children and 22 BECTS patients were recorded in order to construct a functional connectivity (FC) network, which was quantified by graph theory (GT).

Results: The mean age of the control group was 7.94 ± 1.89 years, and the mean age of BECTS patients was 8.14 ± 1.73 years. Our results show that the WISC-IV index scores in the BECTS group were significantly lower than those in the control group. Besides, the FC network pattern of BECTS patients changed significantly in the 12-30, 30-80, and 250-500 Hz frequency band. The local functional connections between posterior cingulate cortex (PCC) and frontal lobe varied significantly in 12-30, 80-250, and 250-500 Hz. Our GT analysis shows that the connection strength of BECTS patients increases significantly in the 12-30 Hz frequency band, the path length decreases significantly in the 12-30 Hz and 30-80 Hz frequency bands, with the clustering coefficient decreasing significantly in the 12-30 Hz, 30-80 Hz, and 250-500 Hz frequency bands. Correlation analysis showed that the full-scale IQ (FSIQ) was positively correlated with the 12-30 Hz clustering coefficient, verbal comprehension index (VCI) was positively correlated with the 250-500 Hz clustering coefficient, perceptual reasoning index (PRI) was positively correlated with the 12-30 Hz clustering coefficient, and perceptual reasoning index (PSI) was negatively correlated with the 12-30 Hz path length.

Conclusion: There is a trend of cognitive impairment in patients with early BECTS. This trend of cognitive impairment in early BECTS children may be related to the changes in the FC network pattern.

Keywords: benign childhood epilepsy with centrotemporal spikes; functional connectivity; graph theory; magnetoencephalography; multi-frequency; neural network.