White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells

Abstract

Brain CD8⁺ CD69⁺ tissue-resident memory T (T_RM ) cells comprise a CD20^dim subset, which is proportionally larger in CD103-negative T_RM cells. In multiple sclerosis (MS) lesions, CD20^dim T_RM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20^dim T_RM cells as a relevant subset in MS.

Keywords: CD20; brain; human; multiple sclerosis; tissue-resident memory T cells.