Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.
Keywords: DNA damage response; Proteostasis; chemotherapy; phosphorylation; prognostic biomarker.
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.