Cross-Dehydrogenative Coupling of Strong C(sp3)-H with N-Heteroarenes through Visible-Light-Induced Energy Transfer

Haitao Tian; Hui Yang; Chao Tian; Guanghui An; Guangming Li

doi:10.1021/acs.orglett.0c02912

Cross-Dehydrogenative Coupling of Strong C(sp³)-H with N-Heteroarenes through Visible-Light-Induced Energy Transfer

Org Lett. 2020 Oct 2;22(19):7709-7715. doi: 10.1021/acs.orglett.0c02912. Epub 2020 Sep 17.

Authors

Haitao Tian¹, Hui Yang¹, Chao Tian¹, Guanghui An^{1

2}, Guangming Li¹

Affiliations

¹ Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, No. 74, Xuefu Road, Nangang District, Harbin 150080, People's Republic of China.
² College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, Heilongjiang 150001, China.

PMID: 32942860
DOI: 10.1021/acs.orglett.0c02912

Abstract

The sustainable cross-dehydrogenative coupling of strong C(sp³)-H with N-heteroarenes has been developed using an efficient organic photocatalyst. It features atomic- and step-economy, and acid-free conditions. Mechanism studies suggest a previous elusive energy transfer pathway from photocatalyst to N-heteroarenes and oxidants.