Near-infrared light control of membrane potential by an electron donor-acceptor linked molecule

Yuta Takano; Kazuaki Miyake; Jeladhara Sobhanan; Vasudevanpillai Biju; Nikolai V Tkachenko; Hiroshi Imahori

doi:10.1039/d0cc05326k

Near-infrared light control of membrane potential by an electron donor-acceptor linked molecule

Chem Commun (Camb). 2020 Oct 20;56(83):12562-12565. doi: 10.1039/d0cc05326k.

Authors

Yuta Takano¹, Kazuaki Miyake², Jeladhara Sobhanan³, Vasudevanpillai Biju⁴, Nikolai V Tkachenko⁵, Hiroshi Imahori⁶

Affiliations

¹ Research Institute for Electronic Science, Hokkaido University, Kita-20, Nishi-10, Sapporo 001-0020, Japan. tak@es.hokudai.ac.jp and Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. imahori@scl.kyoto-u.ac.jp and Graduate School of Environmental Science, Hokkaido University, Kita-10, Nishi-5, Sapporo 060-810, Japan.
² Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
³ Graduate School of Environmental Science, Hokkaido University, Kita-10, Nishi-5, Sapporo 060-810, Japan.
⁴ Research Institute for Electronic Science, Hokkaido University, Kita-20, Nishi-10, Sapporo 001-0020, Japan. tak@es.hokudai.ac.jp and Graduate School of Environmental Science, Hokkaido University, Kita-10, Nishi-5, Sapporo 060-810, Japan.
⁵ Faculty of Engineering and Natural Sciences, Tampere University, Korkeakoulunkatu 8, Tampere FI-33720, Finland. nikolai.tkachenko@tuni.fi.
⁶ Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. imahori@scl.kyoto-u.ac.jp and Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.

PMID: 32940286
DOI: 10.1039/d0cc05326k

Abstract

Near-infrared (NIR) light control of living cellular activities is a highly desired technique for living cell manipulation because of its advantage of high penetrability towards living tissue. In this study, (π-extended porphyrin)-fullerene linked molecules are designed and synthesized to achieve NIR light control of the membrane potential. A donor-(π-extended porphyrin)-acceptor linked molecule exhibited the formation of the charge-separated state with a relatively long lifetime (0.68 μs) and a moderate quantum yield (27-31%). The hydrophilic trimethylammonium-linked triad molecule successfully altered PC12 cells' membrane potential via photoinduced intramolecular charge separation.