Photothermal and adsorption effects of silver selenide nanoparticles modified by different surfactants in nursing care of cancer patients

Xingju Yang; Chen Wang; Xiaoxu Zhang; Yue Wang; Feng Gao; Lixia Sun; Wenli Xu; Changxiu Qiao; Guiqin Zhang

doi:10.1080/14686996.2020.1800367

Photothermal and adsorption effects of silver selenide nanoparticles modified by different surfactants in nursing care of cancer patients

Sci Technol Adv Mater. 2020 Sep 1;21(1):584-592. doi: 10.1080/14686996.2020.1800367.

Authors

Xingju Yang¹, Chen Wang², Xiaoxu Zhang³, Yue Wang³, Feng Gao⁴, Lixia Sun¹, Wenli Xu³, Changxiu Qiao⁵, Guiqin Zhang¹

Affiliations

¹ Department of Nursing, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan China.
² Neurointerventional Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³ The Intensive Care Unit (ICU), Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan China.
⁴ Tumor Department, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan China.
⁵ Nursing School of Binzhou Medical University, Binzhou, China.

Abstract

Silver selenide nanoparticles have advantages of low cytotoxicity, desirable near-infrared light response characteristics, and easy surface modification, which attract increasing attention in chemo-photothermal therapy and nursing care of cancer patients. In this contribution, we synthesized Ag₂Se nanoparticles modified by the surfactant of cetyltrimethylammonium bromide (CTAB) using a ligand exchange strategy. Their microstructure and composition were characterized by transmission electron microscopy, X-ray diffraction, X-ray Photo-electronic Spectroscopy, and Fourier transform infrared spectroscopy. The CTAB modified Ag₂Se nanoparticles exhibited a uniform diameter distribution centered at ~12 nm. In order to investigate the photothermal and adsorption effects of CTAB-Ag₂Se nanocomposites, we also prepared sodium dodecyl benzene sulfonate (SDBS) modified Ag₂Se nanoparticles to make a comparison. The CTAB-Ag₂Se nanoparticles showed high photothermal properties, a photothermal conversion efficiency of 20.1% and a high drug adsorption performance of 48.2 μg/mg. Importantly, the CTAB-Ag₂Se-DOX presented an MCF-7 cell activity of only 27.3% under near-infrared radiation. The results revealed that the surface-modified Ag₂Se nanoparticles with CTAB had stronger antitumor ability.

Keywords: 212 Surface and interfaces; 301 Chemical syntheses / processing; 503 TEM; SEM; STEM; Synthesis; characterization; photothermal; silver selenide; surfactants.