Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer

Ching-Hsiung Lin; Po-Jen Yang; Sheng-Hao Lin; Kun-Tu Yeh; Thomas Chang-Yao Tsao; Yu-En Chen; Shu-Hui Lin; Shun-Fa Yang

doi:10.3390/diagnostics10090692

Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer

Diagnostics (Basel). 2020 Sep 14;10(9):692. doi: 10.3390/diagnostics10090692.

Authors

Ching-Hsiung Lin^{1

2

3}, Po-Jen Yang^{4

5}, Sheng-Hao Lin^{1

2

3}, Kun-Tu Yeh^{4

6}, Thomas Chang-Yao Tsao^{4

7}, Yu-En Chen⁶, Shu-Hui Lin^{6

8}, Shun-Fa Yang^{9

10}

Affiliations

¹ Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.
² Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.
³ Department of Recreation and Holistic Wellness, MingDao University, Changhua 500, Taiwan.
⁴ School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
⁵ Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
⁶ Department of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.
⁷ Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
⁸ Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 402, Taiwan.
⁹ Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
¹⁰ Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.

Abstract

EGFR mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification of EGFR mutation-related phenotypes by antioxidant gene polymorphism status can be an effective approach in terms of improving the prognosis of lung cancer patients. The present study was designed to evaluate the distribution frequency of antioxidant gene polymorphisms in lung adenocarcinoma, as well as its association with hotspot EGFR mutations. The study findings revealed that a statistically significant association exists between EGFR L858R mutation and AG + GG genotypes of SOD rs4880 polymorphism. Furthermore, the subgroup analysis data revealed that compared to AA genotype of SOD rs4880, AG + GG genotypes were significantly associated with advanced cancer stage and distant metastasis. Taken together, these findings can be utilized clinically to predict cancer aggressiveness, metastatic, potential and therapeutic responsiveness of lung cancer patients.

Keywords: EGFR mutation; adenocarcinoma; antioxidant gene polymorphisms.