Antibacterial Triketone-Phloroglucinol-Triketone Adducts from Myrtus communis

Chem Biodivers. 2020 Nov;17(11):e2000708. doi: 10.1002/cbdv.202000708. Epub 2020 Nov 2.

Abstract

Myrtucyclitones A-C ((+)- and (-)-1-3), three pairs of new triketone-phloroglucinol-triketone hybrids were isolated from the plant Myrtus communis. Their structures with absolute configurations were established by NMR analysis and chemical calculations. Myrtucyclitones B and C exhibited remarkable antibacterial effect.

Keywords: Myrtus communis; antibacterial effect; triketone-phloroglucinol-triketone adduct.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Circular Dichroism
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Ketones / chemistry*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Myrtus / chemistry*
  • Myrtus / metabolism
  • Phloroglucinol / chemistry*
  • Plant Leaves / chemistry
  • Plant Leaves / metabolism
  • Plant Stems / chemistry
  • Plant Stems / metabolism

Substances

  • Anti-Bacterial Agents
  • Ketones
  • Phloroglucinol