Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Sihan Wu; Paul S Mischel

doi:10.1016/j.ccell.2020.08.012

Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Cancer Cell. 2020 Sep 14;38(3):311-313. doi: 10.1016/j.ccell.2020.08.012.

Authors

Sihan Wu¹, Paul S Mischel²

Affiliations

¹ Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.
² Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA; Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA; Department of Pathology, University of California at San Diego, La Jolla, CA, USA; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. Electronic address: pmischel@health.ucsd.edu.

PMID: 32931740
DOI: 10.1016/j.ccell.2020.08.012

Abstract

Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

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MeSH terms

Brain Neoplasms* / genetics
Brain Neoplasms* / therapy
Cell Lineage
Glioblastoma* / genetics
Glioblastoma* / therapy
Humans