Dronedarone-Mediated Acute Hepatic and Renal Toxicity

Zarak H Khan; Kashif Mukhtar; Munis M Ahmed; Syeda Ramsha Zaidi; Randa Abd Algayoum

doi:10.7759/cureus.9611

Dronedarone-Mediated Acute Hepatic and Renal Toxicity

Cureus. 2020 Aug 7;12(8):e9611. doi: 10.7759/cureus.9611.

Authors

Zarak H Khan¹, Kashif Mukhtar¹, Munis M Ahmed^{1

2}, Syeda Ramsha Zaidi¹, Randa Abd Algayoum¹

Affiliations

¹ Internal Medicine, St. Mary Mercy Hospital, Livonia, USA.
² Internal Medicine, King Edward Medical University, Lahore, PAK.

Abstract

Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where it has led to rapid onset of liver failure. We present the case of an 86-year-old male who developed acute liver failure concomitantly with acute kidney failure after he was started on dronedarone therapy.

Keywords: acute liver failure; acute renal injury; dronedarone.

Publication types

Case Reports