Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms

Mrinmoy Das; Emmanuel Stephen-Victor; Jagadeesh Bayry

doi:10.1080/2162402X.2020.1773193

Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms

Oncoimmunology. 2020 Jun 5;9(1):1773193. doi: 10.1080/2162402X.2020.1773193.

Authors

Mrinmoy Das¹, Emmanuel Stephen-Victor¹, Jagadeesh Bayry²

Affiliations

¹ Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
² Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe - Immunopathologie et Immunointervention Thérapeutique, Sorbonne Université, Université de Paris, Paris, France.

Abstract

Basophils play an important role in orienting Th2 immune response, and in the pathogenesis of allergic and inflammatory disorders. However, the mechanism by which basophils are kept in check remains unclear and hence we explored the role of regulatory T cells (Treg cells) in this process. We demonstrate that human Treg cells do not suppress rather induce activation of basophils, and promote Th2 responses by IL-3 and STAT5-dependent mechanism.

Keywords: Basophil; CD4+CD25+FoxP3+ regulatory T cell; cancer; immune evasion; Tregs; Th2 response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Basophils / metabolism
Forkhead Transcription Factors / metabolism
Humans
Interleukin-3
STAT5 Transcription Factor* / metabolism
T-Lymphocytes, Regulatory* / metabolism

Substances

Forkhead Transcription Factors
Interleukin-3
STAT5 Transcription Factor

Grants and funding

Supported by the Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université, Université de Paris, Agence Nationale de la Recherche, France (ANR-19-CE17-0021(BASIN)).