Emergence of Haemophilus parainfluenzae resistant to third-generation cephalosporins in Italy: potential role of PBP3 and PBP5 substitutions in high-level resistance

Int J Antimicrob Agents. 2020 Nov;56(5):106159. doi: 10.1016/j.ijantimicag.2020.106159. Epub 2020 Sep 9.

Authors

Luigi Principe¹, Odette J Bernasconi², Valentina Viaggi³, Edgar I Campos-Madueno², Andrea Endimiani², Francesco Luzzaro³

Affiliations

¹ Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco (Italy). Electronic address: luigi.principe@gmail.com.
² Institute for Infectious Diseases, University of Bern (Switzerland).
³ Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco (Italy).

PMID: 32919010
DOI: 10.1016/j.ijantimicag.2020.106159

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Cephalosporins / therapeutic use*
Community-Acquired Infections / drug therapy
Community-Acquired Infections / microbiology
Drug Resistance, Multiple, Bacterial / genetics*
Genome, Bacterial / genetics
Haemophilus Infections / drug therapy*
Haemophilus Infections / microbiology
Haemophilus parainfluenzae / drug effects
Haemophilus parainfluenzae / genetics*
Haemophilus parainfluenzae / isolation & purification
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Penicillin-Binding Proteins / genetics*
Penicillin-Binding Proteins / metabolism

Substances

Anti-Bacterial Agents
Cephalosporins
Penicillin-Binding Proteins