Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx

G V Kakurina; E S Kolegova; E E Shashova; V V Velikaya; Zh A Startseva; O V Cheremisina; E L Choinzonov; I V Kondakova

doi:10.1007/s10517-020-04918-2

Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx

Bull Exp Biol Med. 2020 Aug;169(4):504-507. doi: 10.1007/s10517-020-04918-2. Epub 2020 Sep 11.

Authors

G V Kakurina¹, E S Kolegova², E E Shashova², V V Velikaya², Zh A Startseva², O V Cheremisina², E L Choinzonov², I V Kondakova²

Affiliations

¹ Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. kakurinagv@oncology.tomsk.ru.
² Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

PMID: 32915364
DOI: 10.1007/s10517-020-04918-2

Abstract

We analyzed the expression of genes encoding proteins involved in cytoskeleton remodeling (RND3, SNAI1, vimentin, cofilin, adenylate cyclase-associated protein 1, ezrin, and profilin) depending on the level of expression of protein phosphatase 1B (PPM1B) mRNA on the example of squamous cell carcinoma of the larynx and hypopharynx. Against the background of a high level of PPM1B expression, a significantly high level of profilin expression was noted. Metastasis correlated with the level of snai1 expression, while relapse after combination treatment was negatively associated with the level of vimentin expression. The obtained new data can reflect molecular peculiarities of the tumor growth in squamous cell carcinoma of the larynx and hypopharynx.

Keywords: actin-binding proteins; progression; protein phosphatase 1B; signaling proteins; squamous cell carcinoma of the larynx and hypopharynx.

MeSH terms

Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism
Cofilin 1 / genetics
Cofilin 1 / metabolism
Cytoskeletal Proteins / genetics
Cytoskeletal Proteins / metabolism
Cytoskeleton / genetics*
Cytoskeleton / metabolism
Cytoskeleton / pathology
Disease Progression
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms / genetics*
Head and Neck Neoplasms / metabolism
Head and Neck Neoplasms / pathology
Humans
Hypopharynx / metabolism
Hypopharynx / pathology
Larynx / metabolism
Larynx / pathology
Neoplasm Recurrence, Local / genetics*
Neoplasm Recurrence, Local / metabolism
Neoplasm Recurrence, Local / pathology
Neoplasm Staging
Profilins / genetics*
Profilins / metabolism
Protein Phosphatase 2C / genetics*
Protein Phosphatase 2C / metabolism
RNA, Messenger / genetics*
RNA, Messenger / metabolism
Signal Transduction
Snail Family Transcription Factors / genetics
Snail Family Transcription Factors / metabolism
Squamous Cell Carcinoma of Head and Neck / genetics*
Squamous Cell Carcinoma of Head and Neck / metabolism
Squamous Cell Carcinoma of Head and Neck / pathology
Vimentin / genetics
Vimentin / metabolism
rho GTP-Binding Proteins / genetics
rho GTP-Binding Proteins / metabolism

Substances

CAP1 protein, human
CFL1 protein, human
Cell Cycle Proteins
Cofilin 1
Cytoskeletal Proteins
PFN1 protein, human
Profilins
RNA, Messenger
SNAI1 protein, human
Snail Family Transcription Factors
VIM protein, human
Vimentin
ezrin
PPM1B protein, human
Protein Phosphatase 2C
RND3 protein, human
rho GTP-Binding Proteins