Circ_0007142/miR-186/FOXK1 axis promoted lung adenocarcinoma progression

Dongjie Ma; Hongsheng Liu; Yingzhi Qin; Danqing Li; Yushang Cui; Li Li; Jia He; Yeye Chen; Xiaoyun Zhou

Circ_0007142/miR-186/FOXK1 axis promoted lung adenocarcinoma progression

Am J Transl Res. 2020 Aug 15;12(8):4728-4738. eCollection 2020.

Authors

Dongjie Ma¹, Hongsheng Liu¹, Yingzhi Qin¹, Danqing Li¹, Yushang Cui¹, Li Li¹, Jia He¹, Yeye Chen¹, Xiaoyun Zhou¹

Affiliation

¹ Department of Thoracic Surgery, Peking Union Medical College Hospital Beijing 100730, China.

PMID: 32913545
PMCID: PMC7476148

Abstract

Circular RNAs (circRNAs) are a class of non-coding RNAs could affect expression of specific genes which may induce tumor occurrence and progression. In this study, we identified 32 differentially expressed circRNAs between five pairs of lung adenocarcinoma and paracancerous tissues using circRNA microarray. And circ_0007142 expression was the most upregulated in five lung adenocarcinoma tissues. Meanwhile, circ_0007142 expression was remarkably over-expressed in lung adenocarcinoma tissues and cells. In addition, knockdown of circ_0007142 inhibited proliferation, migration, invasion and induced apoptosis of lung adenocarcinoma cells. Furthermore, knockdown of circ_0007142 inhibited the biological behavior of lung adenocarcinoma through miR-186/FOXK1 axis and inactivated the Wnt/β-catenin signaling pathway. Altogether, our study suggests Circ_0007142/miR-186/FOXK1 axis may play as an important role in progression of lung adenocarcinoma, which provided a novel potential mechanism about this disease.

Keywords: FOXK1; Lung adenocarcinoma; Wnt/β-catenin signaling pathway; circ_0007142; miR-186.