Transmission of highly spectral efficient 24.5 GBaud quadrature phase shift keying and 16- and 64-quadrature amplitude modulated signals in the S-band between 1492 nm and 1518 nm wavelength is demonstrated over 55 km few-mode fibers. The carrier lines for S-band transmission were generated by a single wideband optical comb source with more than 120 nm optical bandwidth. While the three-mode fiber was originally optimized for C- and L-band transmission, we show that differential mode delay and mode-dependent loss show only a minor wavelength dependence within the measured S-band channels. However, the transceiver sub-system, including S-band optical amplifiers as well as a reduced optical signal-to-noise ratio of the comb source, leads to a significant Q-factor penalty for channels towards the edges of the S-band optical amplifiers below 1495 nm and above 1515 nm wavelength.