Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries

Fengcai Yan; Feng Shi; Xinbao Li; Chunkai Yu; Yulin Lin; Yan Li; Mulan Jin

doi:10.2147/CMAR.S264474

Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries

Cancer Manag Res. 2020 Aug 21:12:7569-7578. doi: 10.2147/CMAR.S264474. eCollection 2020.

Authors

Fengcai Yan^{1

2}, Feng Shi^{1

2}, Xinbao Li³, Chunkai Yu¹, Yulin Lin³, Yan Li^{1

3}, Mulan Jin²

Affiliations

¹ Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.
² Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China.
³ Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.

Abstract

Objective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.

Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.

Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.

Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.

Keywords: PMP; mucinous tumor; ovary; pseudomyxoma peritonei.

Grants and funding

This project was supported by grants from the Beijing Municipal Natural Science Foundation, China (7172108). We would like to thank all the participants for their contribution to this research project.