Data on antiplatelet aggregation, anticoagulation and antioxidant activities of Canna edulis Ker rhizome and its secondary metabolites

Thi Minh Hang Nguyen; Hong Luyen Le; Quoc Hung Tran; Thi Thoa Ha; Bich Hau Bui; Nguyen Thanh Le; Van Hung Nguyen; Thi Van Anh Nguyen

doi:10.1016/j.dib.2020.106115

Data on antiplatelet aggregation, anticoagulation and antioxidant activities of Canna edulis Ker rhizome and its secondary metabolites

Data Brief. 2020 Aug 1:32:106115. doi: 10.1016/j.dib.2020.106115. eCollection 2020 Oct.

Authors

Thi Minh Hang Nguyen¹, Hong Luyen Le², Quoc Hung Tran³, Thi Thoa Ha¹, Bich Hau Bui², Nguyen Thanh Le¹, Van Hung Nguyen¹, Thi Van Anh Nguyen²

Affiliations

¹ Center of Drug Research and Development, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
² Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
³ Lam Dong Medical College, Da Lat, Vietnam.

Abstract

Canna edulis Ker rhizome has been used in Traditional Vietnamese Medicine to prevent and treat heart diseases without thorough scientific evidence. The data presented in this article characterize the antiplatelet aggregation, anticoagulant and antioxidant activity of C. edulis rhizome extracts and the bio-guided isolation of bioactive compounds from the active fraction. The data on tested bioactivities of isolated compounds were also provided. The inhibitory effect on adenosine diphosphate- and collagen-induced human platelet aggregation was evaluated through three parameters: percentage inhibition of platelet aggregation, aggregation velocity and area under the platelet aggregation curve. Prothrombin time, activated partial thromboplastine time and thrombine time were measured to examine the anticoagulant activity. The free radical scavenging ability was assessed with DPPH and ABTS assays. The structures of compounds were elucidated by NMR and MS spectroscopic methods. The data showed that the ethyl acetate fraction showed the most potent antiplatelet aggregation, anticoagulant and antioxidant activity. Seven known compounds: 5-hydroxy-6-methyl-2H-pyran-2-one (1), epimedokoreanone A (2), nepetoidin B (3), ferulic acid (4), caffeic acid (5), hydroxytyrosol (6), and 1H-indole-3-carboxaldehyde (7) were isolated from this active fraction. Moreover, this article provided experimental data on antiplatelet effect of epimedokoreanone A (2) and nepetoidine B (3), anticoagulant and antioxidant activity of epimedokoreanone A (2) and also antiplatelet and antioxidant activity of 5-hydroxy-6-methyl-2H-pyran-2-one (1).

Keywords: Anticoagulant; Antioxidant; Antiplatelet; Canna edulis Ker; Flavonoids compounds.