Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial

Mahmood A Al-Azzawi; Mohamed M N AboZaid; Reda Abdel Latif Ibrahem; Moustafa A Sakr

doi:10.1016/j.heliyon.2020.e04711

Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial

Heliyon. 2020 Aug 13;6(8):e04711. doi: 10.1016/j.heliyon.2020.e04711. eCollection 2020 Aug.

Authors

Mahmood A Al-Azzawi¹, Mohamed M N AboZaid², Reda Abdel Latif Ibrahem³, Moustafa A Sakr⁴

Affiliations

¹ Department of Medical Biochemistry, College of Dentistry, Al-Ayen University, An-Nasiriyah, Iraq.
² Department of Chest Diseases, Zagazig Faculty of Medicine, Zagazig University, Egypt.
³ Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Egypt.
⁴ Molecular Diagnostics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat City, Egypt.

Abstract

This study sought to examine whether supplementation of Black Seed Oil (BSO) can improve pulmonary function tests (PFTs), inflammation, and oxidant-antioxidant markers in COPD patients. The study involved 100 patients of mild to moderate COPD divided randomly into 2 groups who were appointed to receive standard medication only (control group) or with additional Black Seed Oil (BSO group). They were assessed initially and after 3 months, 44 patients responded in control group and 47 patients in BSO group. BSO group evidenced a significant decreasing in oxidant and inflammatory markers; thiobarbituric acid reactive-substances (TBARS), protein carbonyl (PC) content, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), a significant increase in antioxidants; superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), vitamin C, and E, and a significant improvement in PFTs versus control group and baseline levels. Supplementation of Black Seed Oil may be an effective adjunct therapy to improve pulmonary functions, inflammation, and oxidant-antioxidant imbalance in COPD patients.

Keywords: Antioxidant; Biochemistry; COPD; Clinical research; Inflammatory; Natural product chemistry; Nigella sativa; Nutrition; Oxidant; Pharmaceutical chemistry; Physiology; Pulmonary functions; Respiratory system.